Procalcitonin to guide antibiotic stewardship in intensive care
نویسندگان
چکیده
منابع مشابه
Antibiotic Stewardship in the Intensive Care Unit
Antimicrobial stewardship encompasses the optimization of agent selection, dose, and duration leading to the best clinical outcome in the treatment or prevention of infection. Ideally, these goals are met while producing the fewest side effects and lowest risk for subsequent resistance. The concept of antimicrobial stewardship can be directly applied to the prescription of empirical antibiotic ...
متن کاملAntibiotic stewardship in the intensive care unit
The rapid emergence and dissemination of antimicrobial-resistant microorganisms in ICUs worldwide constitute a problem of crisis dimensions. The root causes of this problem are multifactorial, but the core issues are clear. The emergence of antibiotic resistance is highly correlated with selective pressure resulting from inappropriate use of these drugs. Appropriate antibiotic stewardship in IC...
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Despite more than 10 years of research into the usefulness of procalcitonin therapy, Hausfater is right to point out that ‘its exact place in the diagnostic process remains to be defined’ [2]. Both the articles of McLean and of Christ-Crain and Müller have proposed further study of alternative novel biomarkers [3,4]. Early diagnosis of sepsis linked to timely but limited use of antibiotics rema...
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INTRODUCTION The development of resistance by bacterial species is a compelling issue to reconsider indications and administration of antibiotic treatment. Adequate indications and duration of therapy are particularly important for the use of highly potent substances in the intensive care setting. Until recently, no laboratory marker has been available to differentiate bacterial infection from ...
متن کاملProcalcitonin-guided diagnosis and antibiotic stewardship revisited
Several controlled clinical studies have evaluated the potential of the infection biomarker procalcitonin (PCT) to improve the diagnostic work-up of patients with bacterial infections and its influence on decisions regarding antibiotic therapy. Most research has focused on lower respiratory tract infections and critically ill sepsis patients. A clinical utility for PCT has also been found for p...
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ژورنال
عنوان ژورنال: The Lancet Infectious Diseases
سال: 2016
ISSN: 1473-3099
DOI: 10.1016/s1473-3099(16)30156-6